TUBERCULOUS MENINGITIS IN BCG VACCINATED AND UNVACCINATED CHILDREN A CLINICAL AND RADIOLOGICAL COMPARATIVE STUDY

Dr. Sikha Maria Siromani; Dr. Srilakshmi

Volume : VII, Issue : X, October - 2018

TUBERCULOUS MENINGITIS IN BCG VACCINATED AND UNVACCINATED CHILDREN A CLINICAL AND RADIOLOGICAL COMPARATIVE STUDY

Dr. Sikha Maria Siromani, Dr. Srilakshmi

Abstract :

Tuberculous Meningitis is the most serious form of Tuberculosis in children the main aim of this study is to assess protective role of BCG vaccination in TBM and compare clinical and radiological features in BCG vaccinated and unvaccinated children. We have done a prospective study in Niloufer Hospital in the year 2016–17. Out of 108 children taken into study 66 were vaccinated 42 were unvaccinated.

Materials and Methods: Children who were taken into the study satisfied the pre–defined criteria for diagnosis of TBM provided they have not received anti tubercular treatment in the last three months.

Results: The analysis showed that the vaccinated children with BCG scar had more focal deficits compared to unvaccinated children. The CT findings show more children with basal enhancement in vaccinated children.

Conclusion: Our study indicates that the outcome of TBM was similar in both BCG vaccinated and unvaccinated children. The better outcome may in part be explained by better mobilization of cell mediated immune response to the infection as reflected in high mean CSF cell count in vaccinated children.