Volume : VII, Issue : VI, June - 2018
TO EVALUATE THE EFFICACY AND SAFETY OF ORMELOXIFEN IN TREATMENT OF MENORRHAGIA
Dr Rajkishori Dandotiya, Dr Paribhashita Mishra
Abstract :
OBJECTIVE: 1.To evaluates the efficacy of Ormeloxifene in the medical management of menorrhagia.2. To findout side effects of
Ormeloxifene.
STUDY DESIGN AND SETTING: The descriptive observational study was conducted in Department of Obstetrics and
Gynecology, G.R.Medical College and Kamla Raja Hospital, Gwalior (Madhya Pradesh) from January 2017 to December 2017.
MATERIAL AND METHOD: One hundred women of reproductive age group with menorrhagia were recruited for the study.
These patients were given ormeloxifene 60 mg twice a week for 12 weeks from first day of periods and once a week for next 12
weeks. Parameters assessed were Mean blood loss (MBL) by PBAC score, duration of bleeding, presence of blood clots and mean
rise in hemoglobin after 6 months of treatment and changes in these parameters were analyzed by student‘s paired‘ tests using
SPSS 16.0 version ,p value ≤ 0.05 was taken as significant.
RESULT: The mean pre–treatment MBL (PBAC score) was 450.5 which reduced to 60 at 6 months with ormeloxifene and was
found to be statistically significant (p–value ≤0.001). Mean duration of bleeding pretreatment was 7.4days which was reduced to
2 days after 6 months of treatment with ormeloxifene. This reduction in duration of bleeding was statistically significant
(P<0.001).The mean rise in hemoglobin was 1.4 which was also statistically significant. The decrease in endometrial thickness in
patients on ormeloxifene was 1.13 which was not significant (p–0.09).
CONCLUSION: Ormeloxifene is very effective in treatment of menorrhagia. It decrease duration of bleeding, passage of blood
clots and improve hemoglobin effectively. Ormeloxifene is accepted well and has good patient compliance due to its minimal
adverse effects, low cost and simple dosage schedule.
Keywords :
Article:
Download PDF
DOI : https://www.doi.org/10.36106/paripex
Cite This Article:
Dr Rajkishori Dandotiya, Dr Paribhashita Mishra, TO EVALUATE THE EFFICACY AND SAFETY OF ORMELOXIFEN IN TREATMENT OF MENORRHAGIA, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-6 | June-2018
Number of Downloads : 153
References :
Dr Rajkishori Dandotiya, Dr Paribhashita Mishra, TO EVALUATE THE EFFICACY AND SAFETY OF ORMELOXIFEN IN TREATMENT OF MENORRHAGIA, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-6 | June-2018