The correlation between serum thyroid hormone levels and first episode of major depressive disorder

Pal V.S; Chauhan Beema; Rastogi Pali; Razdan R

Volume : IX, Issue : I, January - 2020

The correlation between serum thyroid hormone levels and first episode of major depressive disorder

Pal V. S, Chauhan Beema, Rastogi Pali, Razdan R

Abstract :

Background: Hypothalamus–pituitary–thyroid (HPT) axis dysfunction has been connected with pathophysiology of depression. The object of this study was to determine serum level of free 3,5,3’–triiodothyronine (T3), free thyroxine (T4) and thyroid–stimulating–hormone (TSH) in drug naive patients with unipolar depression and healthy controls. Methodology: The study included 100 medication–free patients with unipolar depression and 100 healthy controls. Results: A higher FT4, lower FT3 and lower TSH mean values which were statistically significant as compared to healthy controls however the means were still in the euthyroid range. Conclusion: The results showing altered levels of thyroid hormones in depression advisable that further research on thyroid hormone activity can contribute to the greater understanding of the biological basis of depression.