The advantages of using mesenchymal stem cells in the treatment of massive burns - case report

Ana-Maria Oproiu; Anamaria Grigore

Volume : VIII, Issue : XII, December - 2019

The advantages of using mesenchymal stem cells in the treatment of massive burns - case report

Ana Maria Oproiu, Anamaria Grigore

Abstract :

Due to insufficient oxygenation of tissues, cellular and vascular destruction, burns show a different healing process from other wounds. Even if it affects only one organ, namely the skin, burns can generate a systematic response in which multiple organs are affected, and the risk of infections and mortality are higher . Therefore, burns require the involvement of several specialities, special care, long hospitalizations and multiple surgical interventions, depending on the the way of production, the surface and the depth. Even if the medicine has evolved, and the mortality of burns has also improved, the healing process is often unsatisfactory with negative consequences on the functional and physical aspects, reducing the quality of the patient`s life. This paper aims to present a different approach in the management of a II–III–degree burns, of approximately 20% body surface, at the level of the posterior thorax and the left upper extremity. This approach consists of using mesenchymal stem cells. The procedure involves the collection of skin samples with a diameter of 5 mm each one, mix them with saline solution, introduce them in a special device, disaggregate them and inject the resulting suspension solution abundant in mesenchymal stem cells into the dermis. The advantages are that it can skip over the excisional deidement stage and the skin graft donor areas are significantly decreased from the standard approach, and other possible subsequent. surgical interventions.