Volume : VII, Issue : VIII, August - 2018
Study of Serum malondialdehyde levels in type 2 diabetics with myocardial infarction
Ruta Anandgaonkar, Dhananjay Bhale, D. M. Vaishnav
Abstract :
Introduction:Diabetes mellitus (DM) increases the incidence of cardiovascular diseases (CVDs) (1 , 2) Although elevated levels of serum MDA have been reported in type 2 diabetes, there is paucity of literature on the extent of serum MDA levels in type 2 diabetes cases with myocardial infarction, a macrovascularcomplication.AIMS AND OBJECTIVES:To measure the levels of serum MDA in type 2 diabetes patients with MI and type 2 diabetes patients without complications.Material and Methods:Type 2 diabetics patients of MGM MC .Aurangabad , were selected. They were divided in two groups.Group I: Thirty patients of either sex diagnosed with Type 2 D.M without any complications. Group II: Thirty patients of either sex having type 2 D.M with myocardial infarction. Control :Thirty patients having similar age groups of either sex comprised the control group; they were non–diabetic, non–hypertensive and non–smokers; METHOD:Estimation of MDA was done by thiobarbituric acid reactive substance assay according to the method described by Mahffouz.[12]RESULTS: In both test–groups the serum MDA level were significantly higher as compared with the controls (P< 0.01) and in between the diabetic groups it was found to be significantly higher in diabetes with myocardial infarction (P< 0.01).CONCLUSION :In diabetic patients a major factor that is responsible for enhanced free radical generation is hyperglycemia through auto–oxidation of glucose; it may be an important risk factor for cardiovascular disease.[13]
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DOI : https://www.doi.org/10.36106/paripex
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Ruta Anandgaonkar, Dhananjay Bhale, D.M. Vaishnav, Study of Serum malondialdehyde levels in type 2 diabetics with myocardial infarction, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-8 | August-2018
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Ruta Anandgaonkar, Dhananjay Bhale, D.M. Vaishnav, Study of Serum malondialdehyde levels in type 2 diabetics with myocardial infarction, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-8 | August-2018