STUDY OF ACQUIRED IMMUNOHAEMOLYTIC ANAEMIA IN LYMPHOPROLIFERATIVE DISORDERS

DR. SUMIT RAY; DR. SENJUTI DAS GUPTA; PROF. SWAPAN KUMAR SINHA

Volume : VIII, Issue : VI, June - 2019

STUDY OF ACQUIRED IMMUNOHAEMOLYTIC ANAEMIA IN LYMPHOPROLIFERATIVE DISORDERS

Dr. Sumit Ray, Dr. Senjuti Das Gupta, Prof. Swapan Kumar Sinha

Abstract :

The study was done to highlight incidence of immunohaemolytic anemia following lymphoproliferative disorder. Five cases of immunohaemolytic anaemia were diagnosed, among cases of lymphoproliferative diseases, during last six years. Age ranged from 44 to 68 years, with four males and one female. They presented with lymphadenopathy, splenomegaly and pallor. EDTA blood was collected for complete haemogram. Blood smear examination, reticulocyte count and bilirubin was done. DAT, serum LDH and CD5 antigen were done. All five patients showed evidence of haemolytic anaemia by presence of normoblasts, polychromatophilia, reticulocytosis, DAT positive, elevated serum LDH & CD5 positive. Four cases were Chronic Lymphatic Leukaemia and one a case of low grade Small Lymphocytic Lymphoma. Approximately 8 – 25% patients develop immunohaemolytic anaemia as a complication of lymphoproliferative disorders . CD5 positive lymphocytes secrete anti DNA antibodies and rheumatoid factors and play significant role in producing auto–antibodies against red cell leading to predominantly warm antibody type of immunohaemolytic anaemia.