Volume : VIII, Issue : V, May - 2019
EXPRESSION OF ER, PR AND HER - 2 / NEU IN BREAST CANCER
Dr. S. P. Smitha Vadana, Dr. S. Swapna
Abstract :
Background: In English literature it is documented that the expression of ER and PR is low in Asian countries when compared to that of Western countries. HER2/NEU over expression is uniform throughout the world. Studies have shown that triple–negative east carcinomas are aggressive, likely to spread beyond the east and recur after treatment. The aim this study is to correlate the expression of ER, PR and HER 2/NEU with clinico–pathological parameters in infiltrating variants of east carcinoma as well as to determine the clinicopathological parameters in triple negative cases. Methods: This is a prospective study for a period of two years in the Department of pathology, Prathima Institute of Medical Sciences, Karimnagar, Tealangana, India as well as Department of Pathology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India during June 2013 to May 2015. All cases clinicopathologically diagnosed as malignant and all age groups were included and were subjected for ER, PR, HER2/NEU receptor study. Results: In the present study total cases analyzed were 52. Infiltrating ductal carcinoma was 29(96.67%) were females and only 1(3.33 %) was male. In our institute infiltrating duct cell carcinoma (NOS) type was the commonest type of carcinoma east with significant group occurring in in–between 46 to 55 of age.In filtratingductal carcinoma ER, PR positive expression has no association with age and size of tumor. Triple negative receptor expression was seen in 54.83% of infiltrating ductal carcinoma. Conclusion: In the present study significant group occurred in between 46–55 years of age presenting in advanced stage of the disease. Triple negative cases were seen in 54.8% cases of infiltrating duct cell carcinoma indicating bad prognosis.
Keywords :
Breast carcinoma Clinicopathological parameters Hormonal status Triple negative cases and ER PR HER2/NEU receptor study
Article:
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DOI : https://www.doi.org/10.36106/paripex
Cite This Article:
EXPRESSION OF ER, PR AND HER‾2 / NEU IN BREAST CANCER, Dr. S.P.Smitha Vadana, Dr.S.Swapna PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-8 | Issue-5 | May-2019
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EXPRESSION OF ER, PR AND HER‾2 / NEU IN BREAST CANCER, Dr. S.P.Smitha Vadana, Dr.S.Swapna PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-8 | Issue-5 | May-2019