Distribution of Headaches and Role of associated Biogenic Amines Metabolites in Blood and Urine

Dr. Vijay singh bhandari; Lt Col Dr. Jeet pal singh rana

Volume : VII, Issue : I, January - 2018

Distribution of Headaches and Role of associated Biogenic Amines Metabolites in Blood and Urine

Dr. Vijay Singh Bhandari, Lt Col Dr. Jeet Pal Singh Rana

Abstract :

Significant number of patients with headache also suffers from psychiatric disorder like depression and psychosis. The pathogenesis of headache and the psychiatric disorders has been explained on the basis of biogenic amine neurotransmitters and peptide. Most of the data on central 5–HT metabolism in depression have been recorded by measuring CSF concentration of 5–HT metabolite, 5–hydroxytindoleacetic acid (5–HIAA) before and after probenecid loading. Blood and urine examination for level of 5–HIAA (major metabolite of serotonin) and HVA (major metabolite of dopamine) was estimated in 262 patients in present study. We observed significant results (p<0.05) in the level of 5–HIAA and HVA in blood of group II. Group I and Group II showed higher values of 5HIAA and HVA in urine than Group V. Present study showed insignificant higher levels of 5HIAA and HVA in Group I and significant lower levels in Grouup II.