COMPARISON OF TIME OF ONSET AND HAEMODYNAMIC EFFECTS OF VECURONIUM BROMIDE WITH ROCURONIUM BROMIDE UNDER GENERAL ANAESTHESIA

Dr.Meena Padmaja Grandhi; Dr.Paturi Madhuri

Volume : VIII, Issue : VI, June - 2019

COMPARISON OF TIME OF ONSET AND HAEMODYNAMIC EFFECTS OF VECURONIUM BROMIDE WITH ROCURONIUM BROMIDE UNDER GENERAL ANAESTHESIA

Dr. Meena Padmaja Grandhi, Dr. Paturi Madhuri

Abstract :

Introduction : Intubation is one of the means of securing airway . Muscle relaxants are useful in providing adequate muscle relaxation to enable laryngoscopy and intubation.the aim of this study was to compare the time of onset of Vecuronium omide with Rocuronium omide for endotracheal intubation and to compare the hemodynamic effects of Vecuronium omide with Rocuronium omide during endotracheal intubation.Method : a total of 50 patientsof ASA G1 and 2 selected for elective surgery are divided into two groups according to randomization plan. One group (Rocuronium group) of 25 patients received Rocuronium 0.6 mg/kg body weight and the other group (Vecuronium group) of 25 patients received Vecuronium 0.1 mg/kg body weight. Parameters observed are Time of onset which is obtained by monitoring for the time from the end of the injection of muscle relaxant until maximum blockade of the first twitch response (T1) of the TOF and Haemodynamic changes which are monitored at 5 settings i.e. 0 min (Base line), 1, 3, 5 and 10 mins . Result : The mean value of onset of action for Rocuronium is 73.6 ± 14.11 and for Vecuronium is 119.2 ± 19.13. In Rocuronium group there is increase in HR from base line which showed a peak at 5 min and decreased at 10 min, but in Vecuronium group there is decrease in HR from base line through out. There was no significant difference of SBP ,DBP and MAP at baseline between the mean values of the two groups. This statistical insignificance has continued at 1, 3, 5 and 10 min after giving relaxants Conclusion ; Both the drugs are found to be equally good for maintaining hemodynamic stability in patients undergoing various surgeries. Rocuronium omide can therefore be advocated as drug of choice where rapid intubation will be beneficial without compromise of haemodynamic stability