Biochemical Approach to the Differential Diagnosis of Metabolic Acidosis in critically ill- children.

Dr. Aruna Kumari Bandaru

Volume : VII, Issue : X, October - 2018

Biochemical Approach to the Differential Diagnosis of Metabolic Acidosis in critically ill- children.

Dr. Aruna Kumari Bandaru

Abstract :

Objective:The aim of the study was to simplify the arterial blood gas analysis and facilitate the differential diagnosis of metabolic acidosis (MA) in critically ill– children.

Methods: A descriptive study was conducted on 150 children admitted in the pediatric intensive care unit were analyzed for acid–base status. The Anion Gap (AG) was calculated to identify the causes of MA. Delta gap and Delta ratio used to assess the presence of mixed acid–base disorders.

Results: There was a significant decrease in means of PH, Bicarbonate (HCO₃^–), and Base Excess, while there is increase in AG between the MA and control groups. There was a significant decrease in HCO₃^–, Chloride, and Chloride: Sodium (Cl^–/Na⁺) ratio, while there was a significant increase in AG, Delta Gap, and Delta Ratio in high AGMA than Normal AGMA.

Conclusion:Cl^–/Na⁺ratio, ∆ Gap, and ∆ Ratio can be used as indicators in differentiating MA.