A study on palliative hypo- fractioned Radiotherapy in carcinoma cervix in multiple clinical conditions

Pramila Kumari; Neeti Sharma; Shankar Lal Jakhad; Kumar H.S

Volume : VIII, Issue : VI, June - 2019

A study on palliative hypo- fractioned Radiotherapy in carcinoma cervix in multiple clinical conditions

Pramila Kumari, Neeti Sharma, Shankar Lal Jakhad, Kumar H. S

Abstract :

Aim: The study aims to apply the palliative hypo fractionated radiotherapy in cervical cancer patients to get rid of the pain, bleeding and obstructive symptoms. Materials and Methods– Between January 2011 to December 2014, 95 patients of cervical cancers, underwent palliative hypo fractionated radiotherapy (RT). Both primary and metastatic regional lymph nodes were treated with 2D–RT technique. Median radiation dose was 30 Gy, 3 Gy daily fraction was delivered. Five out of total patients were excluded from study, due to acute intestinal obstruction and the remaining 90 patients were reviewed. Results: Most common presenting symptom were bleeding and pelvic pain. Total follow up period was 15.6 months (range,5.5 to 22 months) and median survival time was 7.8 months (range, 4 to 24 months).The overall response rates were 90.8% and 65.6% for vaginal bleeding control and pelvic pain control, respectively. 45 patients (50%) patients did not have any acute side effects and 42 (46.66%) patients showed low grade toxicity(1,2),and only 3(3.33%) patients exhibited high grade(3,4) gastrointestinal toxicity which were treated satisfactorily. Late side effects occurred in 12 (13.3%) patients; only of grade 1 or 2. Conclusion: Short–course palliative Radiotherapy is well tolerated, less time consuming and effective for relieving the major symptoms of uterine cervical cancer.