A STUDY OF HEMODYNAMICS WHEN DIFFERENT DOSES OF DEXMEDETOMIDINE IS USED WITH PROPOFOL AS AN INDUCING AGENT

Dr Tamanna Ahemad

Volume : VIII, Issue : II, February - 2019

A STUDY OF HEMODYNAMICS WHEN DIFFERENT DOSES OF DEXMEDETOMIDINE IS USED WITH PROPOFOL AS AN INDUCING AGENT

Dr Tamanna Ahemad

Abstract :

Intravenous dexmedetomidine is associated with a biphasic BP response. At low doses the dominant action of α2 adrenoreceptor agonist activation is a reduction in sympathetic tone, mediated by a reduction of noradrenaline release at the neuroeffector junction, and a inhibition of neurotransmission in sympathetic nerves . The net effect of dexmedetomidine action is a significant reduction in circulating catecholamine’s with a slight decrease in BP and a modest reduction in heart rate. When administered as a continuous infusion, it is associated with a stable hemodynamic response. Significant hypotension is usually only observed in patients with pre–existing hypovolemia or vasoconstriction. The adycardia frequently seen after the administration of dexmedetomidine may be due to the central sympatholytic action, enhanced vagal activity and partly by baroceptor reflex. Hemodynamic stability provided by α2 adrenoceptor agonists in the perioperative period leads to a reduction in perioperative myocardial ischemia.