A CLINICAL COMPARATIVE STUDY BETWEEN INTRAVENOUS NALBUPHINE VERSUS INTRAVENOUS DEXMEDETOMIDINE IN ATTENUATING THE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND INTUBATION

Dr. Ismatara Begum; Dr. Mukesh Patir; Dr. Deba Gopal Pathak

Volume : VIII, Issue : II, February - 2019

A CLINICAL COMPARATIVE STUDY BETWEEN INTRAVENOUS NALBUPHINE VERSUS INTRAVENOUS DEXMEDETOMIDINE IN ATTENUATING THE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND INTUBATION

Dr. Ismatara Begum, Dr. Mukesh Patir, Dr. Deba Gopal Pathak

Abstract :

Background:–The haemodynamic stress during laryngoscopy and intubation may have detrimental effects in high risk patients.The objective of this study is to compare the analgesic potential, any side effects and the attenuation of haemodynamic response by Nalbuphine and Dexmedetomidine to laryngoscopy and endotracheal intubation. Methods:–80 patients, aged 18–60 years,of ASA grade I and II were randomly divided into two groups of 40 each. Group A received Inj.Nalbuphine 0.2mg/kg body weight slow i.v. and Group B received Inj.Dexmedetomidine 1μg/kg body weight in 100ml Normal saline (NS) i.v. over 10 min, at 3 min prior to intubation. The baseline heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) & SpO2% were recorded. Thereafter, haemodynamic parameters and post–operative complications were recorded at various intervals. Postoperative analgesia was assessed by VAS score. Results:–Intraoperatively there was no significant difference in the heart rate, SBP and DBP of patients of both the groups (P–value > 0.05). However, there was a transient rise in SBP and DBP, and a fall in HR at just immediately after the administration of Dexmedetomidine in Group B (P–value < 0.05). The mean duration of analgesia in Nalbuphine group was 5hours 15min and that of Dexmedetomidine group was 2hours 50min and with minimal side effects in both the groups. Conclusion:–Both the study drugs – Nalbuphine 0.2mg/kg and Dexmedetomidine 1μg/kg were effective in attenuating the haemodynamic response to laryngoscopy and intubation. Duration of analgesia and post operative analgesia were better in Nalbuphine group in our study and with minimal side effects in both the study groups.