IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-9-8-26722 Original Research Paper Diabetes mellitus and thyroid dysfunction: A double edged sword. Sadaf Ali Dr. Dr. Shiekh Amir Dr. August 2020 9 8 01 02 ABSTRACT

Interlinking mechanism of thyroid disorders in diabetes mellitus has been suggested by various studies. Inter–connections at the molecular level such as the common signalling pathways explain the linkage. Untreated and undiagnosed thyroid disorders may affect insulin sensitivity and resistance thereby hampering glycaemic control in diabetic patients. Aims and objectives: To know thyroid functioning and spectrum of dysfunctions in type 2 diabetic patients. Materials and methods: Serum samples were obtained from 95 diabetic patients of both genders. Patients who visited the Department of Medicine of Yenepoya Hospital for treatment were taken for the purpose of this study. Some of the patients were on treatment with oral hypoglycaemic drugs and some on insulin or both. Patients were divided into two groups based on duration of disease. Levels of T3, T4 and TSH were measured in all the patient samples using VITROS 5600 analyser. Results: In our study population hypothyroidism was more common in diabetic females when compared to the diabetic male subjects. Similar results were seen in sub–clinical hypothyroidism; which was more commonly found in female patients. Possible reason for this may be attributed to hormonal imbalance in women.