Aim: To compare multiple clinical scoring systems & modified CT severity index for diagnosing in acute pancreatitis. Material and method: This prospective randomized clinical study was conducted among 50 subjects in the Department of General surgery, Muzaffarnagar Medical College & Hospital, Muzaffarnagar, Uttar Pradesh during the period 2017–2019. The physical examination focusing on abdomen and chest was performed. Specific blood tests were done to identify pancreatic inflammation (elevated amylase/ lipase). Imaging tests were done to exclude other diagnosis, confirm the diagnosis of acute pancreatitis and assess the quantitative disease severity based on Ranson’s scoring, PANC3 score, CRP level, HAPS score and MCTSI. Results: In our study population, most sensitive clinical parameter for prediction of prognosis of AP was PANC3score followed by Ranson’s score while CRP level was found to be least sensitive. Most specific clinical parameter was also PANC3 score followed by Ranson’s score and CRP level was found to be least specific. Hence, most accurate clinical parameter for prediction of prognosis in acute pancreatitis was PANC3 followed by Ranson’s score. Conclusion: MCTSI is a good prognostic indicator in predicting the incidence of local complications in acute pancreatitis.