Direct laryngoscopy and endotracheal intubation are associated with increase in sympathoadrenal activity results in hemodynamic instability. Many strategies were used to attenuate this response. Dexmedetomidine is one of the primary drug being used for this purpose. This study was designed to compare the effect of intravenous 0.5μg/kg, 0.75μg/kg, 1μg/kg dexmedetomidine to laryngoscopy and intubation. This study was conducted on 75 patients allotted into 3 groups 25 patients each. Group A –Inj. Dexmedetomidine 0.5 µg/kg. B – 0. 75µg/kg. C– 1µg/kg. vitals, sedation score were observed. After giving Inj. dexmedetomidine in a dose of 0.5,0.75 and 1 μg/kg change in HR at 10 minutes after laryngoscopy and intubation was 5.47%, 10.80% and 18.38% respectively, change in the SBP was 7.71%,14.69%,16.96% respectively, change in the DBP was 6.96%,13.40%,18.01%. We have found that effective dose to blunt the hemodynamic response to laryngoscopy &intubation is 0.5 μg/kg.