The pandemic of coronavirus disease 2019 (COVID–19) infection has emerged as a serious health crisis. Although the majority of the patients predominantly have a respiratory tract infection, while 5–15% of the patient progress to severe disease and critical illness with multisystem involvement. Coagulation system involvement with different coagulation abnormalities is seen in severe and critical patients with increased mortality. The common coagulation abnormalities frequently seen in COVID19 infection are DIC, thromboembolism, thrombocytopenia and increased D–dimer. The coagulation abnormalities in COVID–19 are slightly different from those seen in sepsis. The increase level of D–dimer is common with profoundly increase in severe disease resulting in a poor prognostic factor. Severely affected patients should be routinely screened with D–dimer, platelet count and PT daily or on alternate day. The suspected case of VTE and PE should go for an early investigation. The prophylaxis with LMWH should start in all severely ill and ICU admitted patients in absence of contraindication.