Background: The modern surgical techniques employed for cataract surgery are safe with few complications which include posterior capsule opacification, corneal edema, clinically apparent cystoid macular edema, retained lens fragment, retinal detachment, endophthalmitis & IOL dislocation. Aim: To compare the rate of posterior capsular opacification & visual outcome after implantation of hydrophilic and hydrophobic single piece acrylic intraocular lenses of the same edge design. Materials & Methods: This is a hospital–based prospective, comparative study conducted on 100 patients having uncomplicated senile cataract who after meeting inclusion & exclusion crieteria, were divided into two groups of 50 cases each, all underwent phacoemulsification surgery with the implantation of either hydrophilic or hydrophobic single piece acrylic intraocular lenses. Visual acuity & best corrected visual acuity post–operatively 1st day, 1st, 4th, 12th & 24th week with the help of snellen’s chart, Posterior capsule opacification classification after slit lamp examination were done in every case. Results: Out of the total of 100 cases, maximum no. were in age group of 51–60 years i.e. 37%, males 58% outnumbered females, 92% cases presented with pre–operative VA of ≤6/36. The earliest development of PCO was seen in the 4th week in group 1 & at 24th week in group 2. Also, incidence of PCO increased from 4% to 30% in group 1 & 4% in group 2 over 24 weeks of follow up. The difference in BCVA in both the groups at the end of weeks was not significant. Conclusion: The present study concludes that PCO formation was more in cases having hydrophilic IOL as compared to hydrophobic IOL after phacoemulsification with PC–IOL cataract surgery. However no significant difference in the postoperative BCVA was found at 6 months in both the groups.