Skeletal tuberculosis is less witnessed as compared to pulmonary tuberculosis. Tuberculosis osteomyelitis is uncommonly seen in the diaphyseal region of bone. It may be confused with Brodie’s abscess due to similar clinical and radiological features. Tuberculosis osteomyelitis of the bone is caused by the Mycobacterium tuberculosis. There is uncertainty with the variants of chronic osteomyelitis, defined as Brodie’s abscess. These two low–virulence clinical cases often lead to delays in diagnosis and progressive bone destruction.