COVID–19 is an illness caused due to Novel Corona Virus 2 now called as Severe Acute Respiratory Syndrome Corona Virus –2 (SARS COV 2).1 Ayurveda considers it as a Janapadodhwamsa Vikara. 2In Ayurvedic view, we can compare virus with an aam. This aam produced virkut rasa dhatu. Ultimately it produced abnormal cell. This cell has abnormal DNA and gens. Protein synthesis occurs in RNA will be abnormal.at last gene which is itself protein molecules will be become abnormal. This genetic material made from abnormal protein is virus The choice of medicine (single and poly–herbo–mineral preparations) used should be Kapha Pittahara, Tridoshahara, Rakta Prasadaka / Shodhak, Agada (Vishahara), Jwarahara, Ashukaari, Bahukalpa Rasayana / Urjaskara (drugs having immune–boosting properties) and potent antimicrobial activities. Herbo–mineral agents possessing above activities which can be used as prophylactic as well as curative measure is been proposed in the study. Considering above concepts, a detailed review is done from Ayurvedic classics and a possible frame work is proposed in regard to Samprapti (pathogenesis), prophylactic and curative aspects of COVID–19 in the study.This review paper is one of the start to think about concept of virus in Ayurvedic view.it will be helpful to combine approach of Ayurved and modern science to think and solve genetic disease.