This study was designed to compare the effectiveness of intravenous Dexmedetomidine & Clonidine to attenuate the hemodynamic responses associated with laryngoscopy and endotracheal intubation in patients undergoing laparoscopic surgery under general anaesthesia. Cardiovascular response to laryngoscopy and endotracheal intubation has always become a challenge for anesthetists .Cardiovascular response may occur in form of hypertension, tachycardia and different types of arrhythmias. These effects may prove disastrous in patients of hypertension, myocardial insufficiency, eclampsia and patients with raised intracranial tension.