Background: Endemic areas such as India do not have common signs and fever symptoms. Unusual manifestations cause medical problems, and may delay the diagnosis of typhoid fever. This research describes the clinical presentation of enteric fever in Nellore, Andhra Pradesh, at a tertiary care centre. Methods: The study was a retrospective observational, hospital–based study conducted at Narayana Medical College, Nellore‘s pediatric unit, from April 1, 2017 to April 31, 2019, over a 24 month period. The parents of the children were told of the research and its aims, and were given written informed consent. This required prior approval from the Institutional Ethics Committee. The study included children aged 12 months–18 years who had 4–6 days or more fever with clinical signs and symptoms of typhoid fever and positive clear tests or typhidotal tests. Which identified the patient’s demographic and clinical characteristics. Results: Results: The study had included a total of 126 patients. The majority of children were 54 patients aged from 1–8 years (42.85 per cent). Of the 126 students, 79 were males and 47 were females. Most of the events, including urban slums, were from 78 per cent of urban areas. Drinking water supply was tap water in 82 percent of cases and bore well water in 18 percent of cases. Just 36.51 per cent of children reported fever that lasted less than a week. Of the cases, 57.15 per cent had fever over a week but less than two weeks. Only 6.34% of patients had fever lasting longer than two weeks. All children registered fever‘s main complaint (100%). The next common complaints registered a 51.58% loss of appetite and headache. The most common sign was toxic look (73.01%), followed by coated tongue (68.25%) and splenomegaly (57.93%). Hepatomegaly was also reported in 34.92% of cases. Conclusions: Clinical presentation of study subjects was similar to current literature studies.