Bilastin is a new approved second generation oral H1 Antihistaminic drug which is generally used in several countries for symptomatic treatment of Allergic Rhinitis (AR), Chronic Urticaria (CU) and hives. Oral bilastine is a non–sedating H1 antihistaminic antagonist. H1–receptor played most vital role in control allergic inflammation by directly interfering with histamine H1 receptor. Allergic rhinitis is not a serious disease but it is globally health problem. Bilastine does not cross blood brain barrier (BBB). Bilastine has not cytochrome p450 activity. Absolute bioavailability of Bilastine 60 – 61 %. Bilastine bioavailability much more in fasting as compare to with meal. With meal decrease the absorption time of bilastine and time increase to reach maximum concentration (Cmax). Bilastine have a great affinity to protein binding 84–94%. Bilastine approximately 95 % excreted out, faeces or stool (67%), urine (33%).