To study the prevalence and type of anemia in patients hospitalized with exacerbations of COPD. To study the hematological changes and degree of dyspnea after treating anemia. To study impact of anemia on quality of life. The current study is a prospective study conducted in the pulmonology department, Kurnool medical college, from July 2018 to June 2019. 120 COPD patients were assessed by the following tests–age, duration of disease, severity of dyspnea, BMI, chest X–Ray, complete blood picture, renal function tests, peripheral smear, C–reactive protein, FEV1.Out of 120 patients, 53 (44.16%) had anemia. Normocytic normochromic anemia is the predominant type. Secondary infections, acute exacerbations, duration of hospital stay, frequent hospitalizations were more in anemic patients. Anemia has a negative impact on the quality of life. Anemia is associated with impaired lung function, increased severity of dyspnea, frequent exacerbations.