IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-9-8-26358 Original Research Paper A prospective randomized study to compare the efficacy of clonidine & dexmedetomidine as adjuvants to ropivacaine for post operative epidural analgesia in lower abdominal surgeries Sheema Bashir Dr. Dr. Mehak Gul Dr. Dr. Showkat Gurcoo Dr. August 2020 9 8 01 02 ABSTRACT

Objectives : To compare the analgesic efficacy , quality , duration of postoperative analgesia, incidence of hemodynamic changes with ropivaciane in lower abdominal surgeries when used in combination with adjuvants (clonidine and dexmedetomidine) through epidural route. The study also includes the comparison of side effect profile of dexmedetomidine and clonidine and need for intravenous rescue analgesia in both groups. Methods : 80 patients were randomly allocated into two groups of 40 each GROUP 1 (RD), (n=40), received 10 ml ropivaciane 0.2% and dexmedtomidine 1µg/kg. GROUP 2 (RC), (n=40), received 10 ml ropivaciane 0.2% and clonidine 2µg/kg. After administering the drug, the following parameters were noted by the independent observer. It included pain score , Onset of analgesia , Peak level of analgesia , Duration of analgesia , Monitoring of vital parameters , Side effects such as nausea, vomiting, respiratory depression, motor blockade , deep sedation , shivering , hypotension and Requirement for IV rescue analgesics . Once the patient asked for additional epidural analgesia (VAS>4) for pain relief during the observation period, the study ended . Results : Our observations allow us to conclude that the epidural route provided adequate analgesia in lower abdominal surgeries in terms of VAS score and overall patient satisfaction and it avoided the need of iv analgesics in both the groups.Dexmedetomidine is a better neuraxial adjuant in comparision to clonidine for providing early onset and prolonged post–operative analgesia and stable cardiorespiratory parameters. Dexmedetomidine significantly prolonged the postoperative analgesia time without increasing the incidence of side effects like nausea, vomiting, pruritis or urinary retention. Conclusion : Dexmedetomidine is a better neuraxial adjuant in comparision to clonidine for providing early onset and prolonged post–operative analgesia and stable cardiorespiratory parameters.