Introduction: Surgical extraction of lower 3rd molar is the common intervention in oral surgery. This procedure is often associated with significant post operative swelling that may have both biological and social implications. Various studies have been done using different anti inflammatory drugs to study their impact on inflammation. Material and Methods: This study was conducted on 15 patients who had undergone surgical removal of bilateral impacted mandibular third molar. The subjects were divided into two groups, group A right side and group B left side. In addition to post operative swelling and pain, trismus was evaluated using two different proteolytic enzymes. Results: One group was administered 1000000 IU of chymoral forte every 8 hours for 3 days post operatively. The other group was administered 10 mg of serratiopaptidase every 8 hours for 3 days post operatively. Swelling, pain and trismus were assessed on the 1st, 3rd and 7th post operative days. The results of the studies were statistically analysed. Conclusion: The results showed chymoral forte was more effective in reduction of swelling in comparison with serratiopaptidase. Both chymoral forte and serratiopaptidase had the same effect on pain and trismus.