Neonatal seizures remain a significant clinical problem and are often refractory to treatment with initial anti–seizure medications. There are only a few treatment options in neonates with seizures because antiepileptic medications such as Phenobarbital, phenytoin and benzodiazepines and are rarely effective in controlling epileptogenesis in neonates. Due to favourable pharmacokinetics and side effects profile and positive efficacy outcomes in neonatal seizures to–date, there is great interest in the use of Levetiracetam in neonates. In this mini review, we discuss the Levetiracetam as an emerging antiepileptic in neonatal seizures