Aim: To comparatively evaluate the bonding efficiency of PEEK – silicone and acrylic resin–silicone using different bonding agents. Settings and Designs: In vitro – comparative study Materials and Methods: For conducting the study, one hundred and forty four specimens (72 each of PEEK and 72 of acrylic resin) were prepared. PEEK specimens were CAD CAM milled while those of acrylic resin were made in heat cure resin. Out of 72 samples of PEEK and 72 of acrylic resin specimen, 24 were bonded to facial silicone without bonding agent, 24 were bonded using platinum primer and 24 were bonded to silicone using cyanoacrylate. Bond strength of each group was evaluated and compared using peel bond strength test using Universal testing machine. Statistical Analysis Used: One way ANOVA, Karl Pearson’s correlation. Results: Comparison of mean bond strength among PEEK–silicone and acrylic–silicone groups shows that no significant difference was present between the control groups and also when primer was used as bonding agent. Acrylic–silicone was having significantly better bond strength than PEEK–silicone when cyanoacrylate adhesive was used. Conclusion: Similar to acrylic resin PEEK can also be used as biomaterial which can be bonded to silicone using primer as adhesive material.