“Prevention is better than cure”. According to WHO “Health is the state of complete physical, mental, and social well–being and not merely an absence of disease or infirmity” in the recent years, this statement has been amplified to include the ability to lead a socially and economically productive life. Ayurveda has own unique fundamental principles such as prevention of disease, maintenance of health and promotion of longevity of life. Ayurvedic classics give special emphasis on preventive aspects like practicing dinacarya, nishacharya,rithucharya,nithya sevaniy ahara, varjana of nidhana sevan and pragnaparadha, undergoing regular rithushodhana etc. these are the important points which have been considered as the most conducive factors for maintenance of life and health. Trayopasthamba consists of ahara (food), nidra (Sleep) and brahmacarya (good conduct). Each upasthamba has its own importance in prevention of disease. Ahara (diet) has been considered as the first one which shows its prime importance. Intake of wholesome and unwholesome diet is responsible for prevention and production of various diseases respectively including life style disorders. in this article, mainly concerned with the various principles of prevention of diseases and maintenance of healthy life is discussed as mentioned in the Ayurveda