BACKGROUND: Sickle cell disease is common in central part of India. It is associated with a large spectrum of renal abnormalities, of which microalbuminuria , is a known predictor of end–stage renal disease. METHODS: Prospective, cross sectional, observational study among known 64 sickle cell disease (homozygous) children with stable steady state. Demographic and clinical findings were recorded. Presence of microalbuminuria was checked. RESULTS: Out of the 224 subjects evaluated with microalbuminuria 36/118 (30.50%) were males while 28/106 (26.41%) were females. Dependent variables of microalbuminuria among subjects with microalbuminuria, comparison of the various social classes (P = 0.170, Pearson Correlation 0.087.), Blood transfusions (P = 0.517, Pearson Correlation 0.137), blood pressure and diastolic BP (P = 0.243, Pearson Correlation 0.042), hospitalizations (P = 0.263, Pearson Correlation 0.072), serum creatinine (P = 0.180, Pearson Correlation 0.022), glomerular filtration rate (GFR) (P = 0.310, Pearson Correlation 0.061) are Statistical no significant, but haemoglobin level (P = 0.003, Pearson Correlation 0.219) was Statistical significant . This increase with age was also noted in other studies and may possibly be as a result of higher number of crisis in these children and disease progression over time. CONCLUSIONS: Renal involvement is common in sickle cell disease. Increasing age and homozygous state were risk factors. Microalbuminuria is a good screening test for early detection of renal involvement.