Endodontic therapy is a delicate process comprised of carefully accessing the pulp chamber and negotiation of the root canal orifices followed by chemo–mehchanical preparation and obturation of the canals. Aggressive cutting of the dentin during procedural steps specially in root canal negotiations can lead to floor perforation. Iatrogenic perforation of the furcation of the multirooted can lead to tooth extraction. The influencing factors include the location and the size of the perforation, potential microbial colonization of the endodontic system, the time lapse between the occurrence of the perforation and repair, and the filling material. There were several materials used to seal different types of perforation defects. MTA is one of these restorative materials that is considered the most effective, biocompatible, non–toxic, and non–irritant,promote bone healing and cementum regeneration. The present case reports describe the non surgical management of extensive pulp chamber floor perforations created iatrogenically during the failed attempts of root canal orifice negotiation.