Background : Chronic non healing ulcer has become a great challenge in diabetic patients. platelet rich plasma is used as it is enriched with growth factors to enhance healing of these chronic wounds in diabetic patients and its efficacy is compared with conventional dressing. Methods: This study was conducted in Indira Gandhi Medical College and hospital, pondicherry from august 2019 to October 2019. A total of 72 diabetic patients admitted for non healing foot ulcer was taken up for this study. 36 patients was treated with conventional dressing and 36 patients was treated with platelet rich plasma dressing(PRP). Size of wound , duration and cost were compared between these two groups. Results: Healing was better in patients who were given PRP dressing compared to conventional dressing based on reduction in size of the wound by 6 weeks. Conclusion : Autologous PRP is effective and safe in diabetic patients with chronic non healing foot ulcer