IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-12-23473 Original Research Paper Corneal collagen crosslinking in the management of advanced non- healing microbial keratitis. Dr. December 2019 8 12 01 02 ABSTRACT

We used CXL as a treatment modality for non –healing corneal ulcer as it strengthens the cornea, reduces risk of corneal perforation which complicate microbial keratitis. Study was conducted on 30 patients. Riboflavin dye was instilled every 3 minutes over the cornea, the cornea being irradiated using a UVX lamp. Then antibiotic/antifungal treatment was given, and patients followed up every 3 days. The study showed the mean age was 55.43±16.50. 60 % patients healed after treatment, 40% were non –healing, in which superficial keratitis had a better prognosis than deep stromal ulcers. Mean improvement in pain according to Wong Baker FACES pain rating scale was 2.59. There was a significant effect on pain improvement (p value <0.01). Mean improvement in vision in log MAR after procedure was 0.16. The study showed that CXL appears to be an effective procedure in treating non–healing microbial keratitis with superficial stromal involvement.