Neurogenic osteoarthropathy or Charcot joint of the shoulder joint is an uncommon disease characterized by painless destruction of joint due to loss of sensory perception of the joint. Appropriate clinical assessment, diagnostic workup and treatment are essential in the management of Charcot joint. Patient education on activity modification is crucial step in management to slow the impairment associated with a Charcot joint. This report highlighted a case of neurogenic osteoarthropathy of the shoulder joint secondary to syringomyelia. The clinical features, pathophysiology, differential diagnosis, diagnostic workup and management options are discussed.