Background and Objectives: Symptomatic gallstones are easy to treat, unfortunately however asymptomatic gallstones are as easy to treat. This creates a problem for health care planners in the form of the financial implications involved, since asymptomatic gallstones are even more c than gallstones associated with symptoms and require no surgical intervention, while the funds diverted towards dealing with them drains the health care establishment of much needed funds in an era of costly health care. In this review we attempt to need no intervention in most cases, thereby saving the patient unnecessary surgery and the health care establishment costs, both in the financial form and in manpower. Materials and Methods: This study is based on 25 patients came to RIMS, Ranchi with Gallstone disease on the period of April 2017 to July 2019. Patients who can benefit from this treatment are those who have small gallstones less than 1 cm in diameter with high cholesterol content. Results and Conclusion: My data conform that UDCA can dissolve radiolucent gallstones even at 4 mg/kg, a dose which after 6 months of treatment induced stone reduction or disappearance in 33% of patients. The success rate improved at the higher doses, 50% of patients showing partial or complete dissolution with 8 mg/kg and 65% with 12 mg/kg. Therefore, I conclude that there is a relationship between the dose employed, over the range of 4–12 mg/kg , and the response in terms of stone dissolution at 6 months.