Background Hepatitis C virus is a small, enveloped, positive–sense single–stranded RNA virus that causes hepatocellular carcinoma and lymphomas. Aim of study– To study the spectrum of presentation of HCV infection in the patients brought in the Medical college Hospital for a period of three months. Methods– A cross sectional study of 200 blood samples with no known history of hemodialysis, blood transfusion or needle injury brought for Testing HCV in a period of three months. Their serum is tested for HCV Abs by rapid immunochromatography, Enzyme Linked ImunoSorbent Assay (ELISA). Results– Out of 200 samples , 56 of male (28%) and 144 (72%) of female patients were screened. 14 samples of patients were detected positive ( 07%) .05 male patients (8.92% ), 09 female patients ( 6.25%) found positive . 100% patient from ICU was positive. 28.57% from Medicine department, 17.39% from Surgery, 10.52% from Gynecology department , 2.44% from OPD were detected positive for HCV. The patients from Ortho, Pediatrics and ENT were found Non –Reactive to the HCV test. Conclusions– 14 ( 7%) patients samples were found positive to HCV , higher than that of earlier studies. Age group of 21– 40 years were found worst affected in the study (71.42%). The present study clearly indicates that a preventive screening of population at large in a well–defined manner is required in India.