IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-12-23329 Original Research Paper Platelet Rich Fibrin : A critical review of the new biomaterial. Surupa Dutta Dr. Prof.(Dr.) Manoj Kumar Singh Dr. Dr. Debarshi Jana Dr. December 2019 8 12 01 02 ABSTRACT

Platelet Rich Fibrin (PRF) is one of the latest procedures that is widely in use in dentistry these days. Out of the many platelet concentrates, platelet rich fibrin is the easiest to prepare with no chemical handling and is the most cost effective. Studies have revealed the presence of various platelet derived growth factors and cytokines released by this platelet concentrate. PRF plays an important role in angiogenesis, immune control and wound protection by epithelial cover. The slow polymerization during PRF preparation seems to generate a fibrin network very similar to the natural one. Such a network leads to a more efficient cell migration and proliferation as compared to fibrin adhesives and concentrated Platelet Rich Plasma( cPRP