Object: – The aim of this study was comparison of the results of use of cyanoacrylate versus paraffin gauze dressing on split thickness skin graft donor site.

Materials & Methods – This prospective study was conducted on 50 patients who were admitted in surgical wards in tertiary care hospital from December 2016 to July 2018 and underwent split skin grafting.

Results– In our study we observed that in cyanoarylate group patients, homeostasis and healing were faster and itching and pain as well as hospital stay was less as compared to paraffin gauze group patients.

Conclusion– Use of cyanoacrylate over donor site is very good in comparison with paraffin gauze dressing of donor site in respect to healing, homeostasis and  time of hospital stay.