Pituitary adenoma (micro and macro) accounts for 15% of all intracranial tumors. Surgery is the mainstay modality for pituitary adenoma. Pituitary adenoma can be asymptomatic or present with features of prolactinoma, Cushing’s disease, and acromegaly. Growth hormone (GH) secreting pituitary adenoma may lead to acromegaly in adults. Secondary Diabetes and Cardiovascular involvement in acromegaly is common and decide the prognosis.A 75 years old male presented to our medical ICU twice; once for ischemic heart disease and other time for sepsis due to diabetic foot infection. Patient had signs of acromegaly with past history of operation for Pituitary macroadenoma. In management of acromegaly, comorbidities play an important role. This patient had suffered due to diabetic complications and ischemic heart disease, and so was treated with medical management and was asked to come for follow up for surgical and multistep therapeutic strategy however did not report consequently.