Volume : VII, Issue : IV, April - 2018
To study the treatment comparison of salmeterol with fluticasone combination and formoterol with fluticasone combination in the management of persistent asthma
Aradhana Sharma, Hemant Tiwari
Abstract :
Background:–The object of this study wastreatment comparison of salmeterol with fluticasone combination versus formoterol with fluticasone combination in the management of persistent asthma.
Material and methods::–This was a randomized, prospective, open–label study conducted in 50 patients of moderate persistent onchial asthma after taking informed consent.After simple randomization patients were enrolled in group–1 and group–2 and compared the effects of 2 weeks of treatment ofsalmeterol, 50 µg with fluticasone propionate 100µg twice daily and formoterol, 6µg with fluticasone propionate 100 µg twice daily .
Result:–Based on findings of this study it was observed that evening mean PEF in group 1 & 2 (38.04± 22.34,32.92±39.16 respectively) was statistically significant (P<0.05) as well asmorning mean PEF in group 1&2 (31.92±15.12, 25.64 ± 14.6) was also statistically significant (P<0.05) . The mean difference of FEV1 % predicted in group–1 and group–2 was 1.41 ± 5.67 which was
not statistically significant (p >0.05) as well as the mean difference of Evening and morning PEFin group–1 and group–2 was also not statistically significant (p >0.05).
Conclusion:–
We conclude that the long–acting ß2–agonist and inhaled cortico–steroid combinations, formoterolwith fluticasone propionate andsalmeterol with fluticasone propionate improve morning and evening PEF, but without any significant difference in efficacy between the two combinations.
Keywords :
PEF(peak expiratory flow) FEV1(forced expiratory volume first second) COPD(chronic obstructive pulmonary disease)
Article:
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DOI : 10.36106/ijsr
Cite This Article:
Aradhana Sharma, Hemant Tiwari, To study the treatment comparison of salmeterol with fluticasone combination and formoterol with fluticasone combination in the management of persistent asthma, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
Number of Downloads : 288
References :
Aradhana Sharma, Hemant Tiwari, To study the treatment comparison of salmeterol with fluticasone combination and formoterol with fluticasone combination in the management of persistent asthma, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018
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