TO STUDY THE PATTERN OF ADVERSE DRUG REACTIONS (ADRS) OF ANTIRETROVIRAL DRUGS IN AIDS PATIENTS ATTENDING ART OUTPATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL - A PROSPECTIVE OBSERVATIONAL STUDY

Femina Dawer; Dr. Abhijeet Joshi; Monisha Chavan

Volume : IX, Issue : VIII, August - 2020

TO STUDY THE PATTERN OF ADVERSE DRUG REACTIONS (ADRS) OF ANTIRETROVIRAL DRUGS IN AIDS PATIENTS ATTENDING ART OUTPATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL - A PROSPECTIVE OBSERVATIONAL STUDY

Femina Dawer, Dr. Abhijeet Joshi, Monisha Chavan

Abstract :

Highly Active Anti–Retroviral Therapy (HAART) is fraught with a high risk of adverse drug reactions (ADRs) and consistent use is required to prevent viral drug resistance and meet treatment goals. We assessed 250 prescriptions of patients attending ART OPD (Out–Patient Department) in our hospital set up after Ethical and MDACS (Mumbai District AIDS Control Society) approval. The data related to drug reactions and relevant investigations were collected and then analysed statistically in Microsoft Excel 2013. Out of 250 prescriptions, drug reactions were observed in 108 prescriptions (43.2%). Most commonly affected patients were males, especially in the age group of 31–40 years. The most common reaction observed was anaemia in 44.4% patients caused due to Zidovudine and the least common was lipodystrophy in 2 % patients due to Stavudine. Thus other drugs of similar classes or different classes should be studied to develop a regimen with a better safety profile.