Synthesis, Characterisation and Antimicrobial Activity Study of (Morpholino (Thiophen–2–Yl) Methyl) Nicotino Hydrazide and its Metal(II) Complexes

M. Syed Ali Padusha; S. Farook Basha

Volume : III, Issue : VII, July - 2014

Synthesis, Characterisation and Antimicrobial Activity Study of (Morpholino (Thiophen–2–Yl) Methyl) Nicotino Hydrazide and its Metal(II) Complexes

M. Syed Ali Padusha, S. Farook Basha

Abstract :

A new Mannich base, namely N-(Morpholino(thiophen-2-yl)methyl)nicotino hydrazide(MTN) was synthesized through Mannich condensation by reacting thiophene-2-carboxaldehyde, morpholine and benzohydrazide as substrate. The structure of the formed compound was characterised by IR, 1HNMR and mass spectroscopy and CHN analyses. Using the above compound as ligand, metal complexes were prepared and their structures were established by elemental analyses, IR , UV-visible spectra, molar conductivity and magnetic moment studies. The results of these study indicate the square planar geometry for all the complexes. Further, the ligand and the metal complexes were tested for antimicrobial activity. Antimicrobial studies revealed that metal complexes possess higher activity than those of the metal salts and ligands.