Synthesis And Studies On Metal Complexes  Of 5–(Furan–2–Yl)–3– (2–Hydroxy Phenyl)1–H  Pyrazole–1–Carbothiohydrazide

P.Saravana Bhava; P.Tharmaraj; S.Johnson Raja

Volume : I, Issue : III, August - 2012

Synthesis And Studies On Metal Complexes Of 5–(Furan–2–Yl)–3– (2–Hydroxy Phenyl)1–H Pyrazole–1–Carbothiohydrazide

P. Saravana Bhava, P. Tharmaraj , S. Johnson Raja

Abstract :

Transition metal complexes of novel pyrazole based heterocyclic ligand 5 - (furan 2-yl) -3- (2 hydroxy phenyl) 1H pyrazole -1- carbo thiohydrazide (ML.H2O); M = Cu(II), Ni (II), Co(II) and Zn(II) ) have been synthesized and studied. All the metal complexes have been characterized with the aid of elemental analyses, molar conductance, magnetic susceptibility measurements, IR, UV-Vis.and EPR, mass spectra and cyclic voltammetric studies. The ligand behaves as a tridentate with O, N and S chromophores. The synthesized complexes are found to be monomeric and non-electrolytic nature by magnetic susceptibility and molar conductance data. The UV-Vis., EPR spectral data of the complexes suggest square planar geometry around the central metal ion. The cyclic voltammetric profiles of the complexes show a quasi-reversible peak. The in vitro biological activities of the compounds tested against bacteria such as Gram positive Staphylococcus aureus and Gram negative Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans by well diffusion method show that all the compounds possess more biological activity than the free ligand.