Study of Hepatic Involvement in Adult Patients Suffering from Dengue Infection in a Tertiary Care Hospital in Kolkata.

Sukanta Debnath; Bikram Das; Mehebubar Rahman; Rama Prosad Goswami

Volume : VIII, Issue : VIII, August - 2019

Study of Hepatic Involvement in Adult Patients Suffering from Dengue Infection in a Tertiary Care Hospital in Kolkata.

Sukanta Debnath, Bikram Das, Mehebubar Rahman, Rama Prosad Goswami

Abstract :

Dengue virus has been found to have profound effect on multiple organs including liver. This Single centre, prospective, observational study evaluated the clinical profile, liver function in dengue infected 125 adult patients admitted at inpatients department and assessed its correlation with clinical severity over 5 days after admission. Clinically 72 % patients were classified as Dengue without warning signs (DWNS), 19 % as Dengue with warning signs (DWWS) and 9% as patients of severe Dengue (SD). SD patients presented significantly earlier by 1day (mean 3.82 days) than others. Hepatomegaly was found in 39% patients, acalculous cholecystitis in 9% & both were significantly more common in SD patients. Mean SGOT & SGPT values were 117.3 IU/L, 114.9 IU/L & 78.9 IU/L, 78.2IU/L at day 1 and day 5 respectively. SGOT above 80 IU/L was observed in 72.7%, 54.2% and 50% of patients with SD, DWWS and DWNS respectively. Only 27.3% patients with SD had raised serum SGPT level >80 IU/L & 9.1% had bilirubin ≥1 mg/dL at day1. Mean INR was significantly higher in day5 (1.05�0.16) compared to day 1(1.00�0.14)