Volume : VII, Issue : VI, June - 2018
Serum levels and discriminating abilities of LDH, 5'NT, aminotransferases in mild and severe preeclampsia
Imran Ahmed Siddiqui, B. Laxmikanth, J Ramarao
Abstract :
Preeclampsia (PE) is a pregnancy specific multisystem disorder characterized by heterogeneous clinical and laboratory findings. There are no clinically useful screening tests to identify the women at risk.
Aims and Objectives: To investigate serum lactate dehydrogenase (LDH) activity in PE and to evaluate the relationship between changes in serum levels of LDH, 5’nucleotidase (5’NT), aminotransferases, uricacid (UA) and urine proteins with the severity of PE and to correlate it to the pregnancy outcome.
Material and Methods: 60 women with PE and 30 women having normal uncomplicated pregnancies, matched for maternal age and gestational age were respectively recruited as cases and control groups. Serum levels of LDH, 5’NT,UA, urea, creatinine, aspartate transaminase (AST), and alanine transaminase(ALT) were estimated along with24 hours urinary proteins. The data were analyzed using SPSS software version 17.0.
Results: There was a statistically significant increase in LDH, 5’NT, UA, ALT and AST in severe and mild PE compared to controls (p<0.05). These changes were more pronounced in severe PE as compared to that of mild PE cases (p<0.05).Among all the variables, the serum LDH and ALT showed better discriminating ability for PE and its severity.
Conclusion: LDH and ALT taken together have shown highest diagnostic efficiency in discriminating PE cases from non–PE controls and are useful in assessing disease severity, as well.
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DOI : 10.36106/ijsr
Cite This Article:
Imran Ahmed Siddiqui, B.Laxmikanth, J Ramarao, Serum levels and discriminating abilities of LDH, 5'NT, aminotransferases in mild and severe preeclampsia, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-6 | June-2018
Number of Downloads : 312
References :
Imran Ahmed Siddiqui, B.Laxmikanth, J Ramarao, Serum levels and discriminating abilities of LDH, 5'NT, aminotransferases in mild and severe preeclampsia, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-6 | June-2018
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