Volume : II, Issue : IX, September - 2013
Sensitive Spectrophotometric Method for the Determination of Niguldipine in Pharmaceutical Formulations
M. Rama Chandraiah, Y. V. Rami Reddy
Abstract :
Simple, sensitive and rapid spectrophotometric methods were developed for the determination of Niguldipine in pharmaceutical formulations. Method A was based on the extractive spectrophotometry and the developed color complex due to the formation ion association complex with Bromothymol blue (BTB) at pH 3.7. The formation of a yellow color solution exhibited maximum absorption at wavelength 380 nm. Method B was based on the yellow color formation due to ion association complex between methyl orange (MO) and Niguldipine at PH 3.7 that exhibited maximum absorption at a wave length of 430 nm. Both ion association complexes were extracted into chloroform and Beer’s law was obeyed over the concentration ranges 4–25 µgml–1 and 2–12 µgml–1 for methods A and B respectively. Both the methods have been successfully applied for the assay of the drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants. The reliability and the performance of the proposed methods were established by point and interval hypothesis tests through recovery studies.
Keywords :
Niguldipine Methyl orange (MO) Bromothymol blue (BTB) Spectrophotometer Bulk drugs and tablet formulations
Article:
Download PDF
DOI : 10.36106/ijsr
Cite This Article:
M. Rama Chandraiah, Y. V. Rami Reddy Sensitive Spectrophotometric Method for the Determination of Niguldipine in Pharmaceutical Formulations International Journal of Scientific Research, Vol : 2, Issue : 9 September 2013
Number of Downloads : 767
References :
M. Rama Chandraiah, Y. V. Rami Reddy Sensitive Spectrophotometric Method for the Determination of Niguldipine in Pharmaceutical Formulations International Journal of Scientific Research, Vol : 2, Issue : 9 September 2013
Our Other Journals...
-
Indian Journal of
Applied Research Visit Website -
PARIPEX Indian Journal
of Research Visit Website -
Global Journal for
Research Analysis Visit Website