Prognostic significance of serum uric acid in patients with acute coronary syndrome undergoing coronary angiography

AMIT MALVIYA; SWAPAN SAHA; ANIMESH MISHRA

Volume : VI, Issue : X, October - 2017

Prognostic significance of serum uric acid in patients with acute coronary syndrome undergoing coronary angiography

Amit Malviya, Swapan Saha, Animesh Mishra

Abstract :

Background: Role of serum uric acid level as a prognostic marker in patients with acute coronary syndrome (ACS) is debatable. Aims and objectives: To evaluate the association of serum uric acid level on outcome in patients with acute coronary syndrome undergoing coronary angiography. Material and methods: 142 patients with acute coronary syndrome were enrolled. Upon overnight fasting serum uric acid level was measured. One year follow–up was done and outcomes were evaluated in terms of major adverse cardiovascular events (MACE). Results: The mean uric acid level was 7.11 mg/dl. In univariate analysis, serum uric acid level was found to be associated with adverse cardiovascular events HR1.283 (95% CI 1.169–1.408; P value 0.007) along with diabetes mellitus, complexity of coronary lesions and left ventricular dysfunction. However, multivariate cox regression analysis showed that uric acid is not independent predictor of adverse cardiovascular events HR1.055 (95% CI 0.953–1.169; P value 0.597). Conclusion: Elevated serum uric acid level is not an independent predictor of adverse outcome in patients with acute coronary syndrome.