Volume : VII, Issue : IX, September - 2018

PRIMARY DIFFUSE LEPTOMENINGEAL GLIOMATOSIS – AN ENIGMA

Shiv Pankaj Khanna, Rigvardhan, Prabal Deb

Abstract :

A 52–years–old male was diagnosed with primary diffuse leptomeningeal gliomatosis (PDLG), which is a rare meningeal neoplasm without any evidence of primary tumour in the parenchyma of the ain or spinal cord. Since the initial reporting by Bailey in 1936, less than 80 cases have been reported. The patient had initially presented with progressive alteration of sensorium of one month with blurring of vision. MRI revealed multiple meningeal deposits, without any ain or spinal parenchymal lesion. Histology of stereotactic biopsy showed an anaplastic astrocytoma displaying immunoreactivity for glial fiillary acidic protein, representing the glial component, against a backdrop of meningeal tissuehighlighted by vimentin–immunoreactivity without epithelial memane antigen–immunoexpression. Though the patient was offered radiotherapy, but after 3 cycles he succumbed to the illness. The present case highlights an unusual location of a common CNS neoplasm, which should be considered as a differential diagnosis of meningeal lesion including treatment–resistant tubercular meningitis.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Shiv Pankaj Khanna, Rigvardhan, Prabal Deb, PRIMARY DIFFUSE LEPTOMENINGEAL GLIOMATOSIS – AN ENIGMA, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-9 | September-2018

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