Volume : II, Issue : VI, June - 2013
Polymerization of Glycine and L–Phenylalanine to Short Homooligopeptides by Nitrobiuret Under Aqueous Conditions
Arthur O. Hawtrey, Mario Ariatti, Johann M. Van Zyl
Abstract :
The reactions between nitrobiuret and the amino acids glycine and L-phenylalanine at pH 10, have been examined by mass spectrometry. Initially, the expected amino acyl biurets are formed, however these may react with a further nitrobiuret molecule yielding the amino acyl biuret N-carboxyanhydride. The anhydride then N-acylates a second amino acid molecule to afford a dipeptide derivative. The process is repeated and peptides up to glycine5, glycine5-biuret, phenylalanine4 and phenylalanine5-biuret have been detected. In addition the unstable N-carboxyanhydrides may also be converted to their respective ureides with loss of CO2. These reactions are of particular interest to the area of pre-biotic chemistry.
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DOI : 10.36106/ijsr
Cite This Article:
Arthur O. Hawtrey, Mario Ariatti, Johann M. Van ZYL Polymerization of Glycine and L-Phenylalanine to Short Homooligopeptides by Nitrobiuret Under Aqueous Conditions International Journal of Scientific Research, Vol : 2, Issue : 6 June 2013
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Arthur O. Hawtrey, Mario Ariatti, Johann M. Van ZYL Polymerization of Glycine and L-Phenylalanine to Short Homooligopeptides by Nitrobiuret Under Aqueous Conditions International Journal of Scientific Research, Vol : 2, Issue : 6 June 2013
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