Volume : IV, Issue : VI, June - 2015

Nifedepin Tocolysis for Preterm Labour

Dr. A. S. Mudholkar, Dr. V. R. Nimbargi

Abstract :

 Preterm labour is defined as any delivery before 37 completd weeks of gestation fron the first day of last menstrual period.A preterm labour increases perinatal morbidity & mortality.Various drugs are being used as tocolytics to prolong pregnancy. We are using calcium channel blocker Nifedepin as tocolytic since last 3 years. Material & method: We have analyzed 60 cases of preterm labour in whom Nifedepin was used as tocolytic. These were the patients with singleton pregnancy between 24 to 34 weeks of gestation having two contractions of 20 seconds in 10 minutes with cervical dilatation less than 3 centimeters, cervical effecement less than 30% & intact memanes.On admission after detail examination 30 mg loading doe of Nifedepin was given orally. Patients were monitered for pulse, blood pressure & arrest of contractions. If there was no tachycardia and/or hypotension & contractions were arrested Capsule Nifedepin retard 2o mg was given 12 hourly for 7 days.Outcomes monitored were duration of prolongation of pregnancy, time taken for complet erelaxtation of uterus,reccurrence of contractions if occuered & side effects Injection Dexamethasone wa given for fetal lung maturation.. Results: 48.34% patients had complete relaxation of uterus in 6–12 hours. In 73.34% patients pregnancy was prolonged for 1–2 weeks. In our study in 2 patients Nifedepin was not successful & preterm delivery occuered within 24 hours.Side effects seen were tachycardia in 11.66% patients, headache was seen in 15.0% patients, 10% patients had hypotension & 1.66% patients had palpitation. These findings were comparable to previous authors. Conclusion: from this we conclude that Nifedepin is safe, effective as tocolytic. The drug is easy to administer & monitor.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.A.S.Mudholkar, Dr.V.R.Nimbargi Nifedepin Tocolysis for Preterm Labour International Journal of Scientific Research, Vol : 4, Issue : 6 June 2015


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